Learn about the indications, mechanisms and side effects of the powerful drug, Methotrexate AKA the Moth-T-Rex-ate!
Some topics you will learn in this infographic:
MTX is indicated as the first-line therapy for moderate to severe rheumatoid arthritis (RA). The mechanism for how it decreases the severity of arthritis is not clear. Prior to treatment with MTX, several pre-treatment interventions should be undertaken including laboratory assessment of CBC, serum creatinine, AST and ALT.
Folic Acid Analog:
MTX is a chemical analog of folic acid. It prevents folic acid metabolism and thus thymidine production because it has a much higher affinity for dihydrofolate reductase than folic acid.
Pulmonary toxicity is associated with methotrexate use, and patients can develop irreversible pulmonary fibrosis. Other pulmonary side effects of this drug include hypersensitivity pneumonitis and bronchitis.
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