Methotrexate

[Infographic] How to Study: Methotrexate

Learn about the indications, mechanisms and side effects of the powerful drug, Methotrexate AKA the Moth-T-Rex-ate!

methotrexate mnemonic infographic

Some topics you will learn in this infographic:

Rheumatoid Arthritis:
MTX is indicated as the first-line therapy for moderate to severe rheumatoid arthritis (RA). The mechanism for how it decreases the severity of arthritis is not clear. Prior to treatment with MTX, several pre-treatment interventions should be undertaken including laboratory assessment of CBC, serum creatinine, AST and ALT.

Folic Acid Analog:
MTX is a chemical analog of folic acid. It prevents folic acid metabolism and thus thymidine production because it has a much higher affinity for dihydrofolate reductase than folic acid.

Pulmonary Fibrosis:
Pulmonary toxicity is associated with methotrexate use, and patients can develop irreversible pulmonary fibrosis. Other pulmonary side effects of this drug include hypersensitivity pneumonitis and bronchitis.

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