This drug is used for its antidepressant properties in patients with major depressive disorder.
The SNRI duloxetine is indicated for diabetic peripheral neuropathy and related neuropathic pain.
Duloxetine is used to treat peripheral diabetic neuropathic pain, and can also used for depression. Other indications for this drug include anxiety, chronic pain and fibromyagia. This drug has a greater effect on NE reuptake inhibition.
Generalized panic and anxiety disorders are indications for use of the SNRI drug, Venlafaxine.
Venlafaxine is a medication that works on serotonergic and noradrenergic receptors, when administered at moderate doses, to help treat anxiety and panic disorders.
The mechanism by which SNRIs work by inhibiting the reuptake of the neurotransmitters serotonin and norepinephrine. This leads to an increase in neurotransmission by increasing the availability of extracellular concentrations of serotonin and norepinephrine.
Hypertension is a side effect of SNRIs, which is attributed to the increased circulating amounts of NE.
The side effect of SNRI associated insomnia is believed to be caused by increased circulating NE.
Nausea and vomiting are typically the most common side effects related to SNRI therapy.
Patients commonly complain of decreased sexual desire (decreased libido), as well as an inability to reach sexual climax (anorgasmia).
Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.
*Average video play time: 2-3 minutes
Unforgettable characters with concise but impactful videos (2-4 min each)