🍂
FALL INTO SAVINGS SAVE UP TO 25%
Medicine (MD/DO)
/
Courses
/
Microbiology
/
Antivirals
/
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)

Master NRTIs (Nucleoside Reverse Transcriptase Inhibitors) with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

DOWNLOAD PDF
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)

NRTIs (Nucleoside Reverse Transcriptase Inhibitors)

Nerd-ties
Picmonic
NRTIs, or nucleoside reverse transcriptase inhibitors, are a class of antiretroviral drugs used to treat HIV. They work by competitively inhibiting nucleotide binding to reverse transcriptase and also terminate the elongating DNA chain. Certain drugs have specific indications; for example, ZDV is used for general prophylaxis and during pregnancy to decrease transmission. This drug class is notable because they must be "activated" in the cell and require phosphorylation.
5 KEY FACTS
INDICATIONS
HIV
AIDS Band-aid

NRTIs are indicated for treating HIV and target reverse transcriptase activity.

Pregnancy and Prophylaxis given ZDV
Pregnant-woman with Purple-axes and Zombie-dove

ZDV, or zidovudine, is a specific NRTI used to provide general prophylaxis as well as for pregnant women who are HIV positive to decrease the risk of fetal transmission.

MECHANISM
Inhibit Nucleotide Binding to Reverse Transcriptase
Inhibiting-chains preventing Reversing Train-script from Binding to Nucleotides

NRTIs are a class of drugs that work by competitively inhibiting nucleotide binding to reverse transcriptase. This inhibition prevents the virus from making a DNA copy of its RNA.

Chain Termination
Chain Stop

By binding to the viral reverse transcriptase, these medications lead to elongating DNA (which is viral) chain termination. A lack of a 3'-OH group in the incorporated nucleotide analogue prevents DNA chain elongation, and therefore, the viral DNA growth is terminated.

Require Phosphorylation
Using Phosphorus-P

NRTIs need to become "activated" and require phosphorylation from the host cell.

DOWNLOAD PDF

Recommended Picmonics

picmonic thumbnail
Ganciclovir
picmonic thumbnail
Foscarnet
picmonic thumbnail
Cidofovir
picmonic thumbnail
Ribavirin
picmonic thumbnail
Zanamivir (Relenza) and Oseltamivir (Tamiflu)

Take the NRTIs (Nucleoside Reverse Transcriptase Inhibitors) Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,960,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.