NRTIs are indicated for treating HIV and target reverse transcriptase activity.
ZDV, or zidovudine, is a specific NRTI that is used to provide general prophylaxis as well as for pregnant women who are HIV positive to decrease the risk of fetal transmission.
NRTIs are a class of drug which work by competitively inhibiting nucleotide binding to reverse transcriptase. This prevents the virus from making a DNA copy of its RNA.
By binding to the viral reverse transcriptase, these medications lead to elongating DNA (which is viral) chain termination. A lack of a 3'-OH group in the incorporated nucleotide analogue prevents DNA chain elongation, and therefore, the viral DNA growth is terminated.
NRTIs need to become "activated" and require phosphorylation from the host cell.
Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.
*Average video play time: 2-3 minutes
Unforgettable characters with concise but impactful videos (2-4 min each)