🍪
'Tis the season sale SAVE 30% now
Registered Nurse (RN)
/
Courses
/
Pharmacological Nursing
/
Diabetic Medications
/
Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors)

Master Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors) with Picmonic for Nursing RN

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

DOWNLOAD PDF
Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors)

Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors)

Sitar-griffin & Sax-griffin
Picmonic
Sitagliptin (Januvia) and saxagliptin (Onglyza) are antidiabetic medications that work by blocking the DPP-4 enzyme, allowing for increased action of incretin hormones and increased release of insulin. These medications are only effective in the presence of insulin and can only be used in patients with type II diabetes. Keep in mind, however, DPP-4 inhibitors are considered adjunctive therapy for the treatment of diabetes and should only be used if monotherapy has failed to provide adequate blood glucose control. Side effects include upper respiratory infection, pancreatitis, and hypersensitivity reactions.
8 KEY FACTS
-gliptin Suffix
Griffins

Medications in this category can be recognized by the “-gliptin” ending.

MECHANISMS
DPP-4 Inhibitor
DiPPer (4) Fork in Inhibiting-chains

Sitagliptin inhibits an enzyme called dipeptidyl peptidase or DPP-4. By blocking this enzyme, sitagliptin increases the action of incretin hormones that work to stimulate insulin release and to decrease glucagon release after meals. Together, these actions prevent a patient from becoming hyperglycemic.

Increases Insulin Release
Up-arrow Insect-syringe Released

DPP-4 inactivates incretin hormones. When DPP-4 is blocked by sitagliptin; however, the action of incretin hormones is increased, thus increasing insulin release.

INDICATIONS
Type 2 Diabetes
Dyed-bead-pancreas in (2) Tutu

These medications are only effective in the presence of insulin and can only be used in patients with type II diabetes. Keep in mind that DPP-4 inhibitors are considered adjunctive therapy for the treatment of diabetes and should be used in conjunction with metformin, SGLT2 inhibitors, or others.

SIDE EFFECTS
Pancreatitis
Pancreas-on-fire

Although rare, patients may develop pancreatitis. Signs and symptoms of this condition include severe abdominal pain and vomiting. Sitagliptin/saxagliptin therapy should be stopped immediately if these symptoms develop.

Upper Respiratory Infection and Inflammation
Upper Respiratory Tract Bacteria In-flames

Patients taking sitagliptin/saxagliptin may develop an upper respiratory infection or inflammation of the sinuses. Signs and symptoms of a URI include runny or stuffy nose, sneezing, sore throat, and a cough.

Stevens-Johnson Syndrome
Steve-Johns

Hypersensitivity reactions such as Stevens-Johnsons syndrome, anaphylaxis, and angioedema can occur. Sitagliptin/saxagliptin therapy should be stopped immediately if these conditions develop.

CONSIDERATIONS
Used as Add-on Agents
Add (+) on Agent

According to the American Diabetes Association, DPP-4 inhibitors are to be used as add-on treatment options. They are indicated if monotherapy has failed to provide adequate blood glucose control.

DOWNLOAD PDF

Recommended Picmonics

picmonic thumbnail
Insulin
picmonic thumbnail
Metformin (Glucophage)
picmonic thumbnail
Mixing NPH and Regular Insulin for Injection
picmonic thumbnail
Chlorpropamide and Tolbutamide (Orinase) (1st Generation Sulfonylureas)
picmonic thumbnail
Acarbose (Precose) and Miglitol (Glyset) (Alpha Glucosidase Inhibitors)

Take the Sitagliptin (Januvia) and Saxagliptin (Onglyza) (DPP-4 Inhibitors) Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Registered Nurse (RN) Classes & Exams with Picmonic:

Over 1,990,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Registered Nurse (RN) student study app.

Picmonic for Registered Nurse (RN) covers information that is relevant to your entire Registered Nurse (RN) education. Whether you’re studying for your classes or getting ready to conquer your NCLEX®-RN, Hesi, ATI, TEAS test, Kaplan exams, we’re here to help.

Works better than traditional Registered Nurse (RN) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.