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DOWNLOAD PDFTOF is the most common cause of blue baby syndrome in newborns. Babies are "blue" due to the cyanosis experienced in this heart disorder.
The acronym âPROVeâ can be used to help remember the four specific abnormalities generally associated with TOF: P for pulmonary infundibular stenosis, R for RVH, O for overriding aorta, V for VSD, and the âeâ is silent without an associated pathology.
One of the tetralogies that can occur is pulmonary infundibular stenosis. Pulmonary infundibular stenosis is described as a narrowing of the right ventricular outflow tract. It occurs at the pulmonary valve, or just below at the infundibulum.
Due to the increased pressure and resistance of the right ventricular outflow tract, the right heart becomes pathologically hypertrophied. This RVH can cause the heart to be visualized as "boot-shaped."
In TOF, the aorta sits above the VSD, giving it biventricular access. This is problematic because deoxygenated blood from the right ventricle can then make its way into systemic blood flow.
Patients with TOF have a VSD which allows deoxygenated blood from the right ventricle to mix with oxygenated blood from the left ventricle. Because pulmonary stenosis causes right-sided outflow obstruction, blood is preferentially pushed toward the left side, and a right-to-left shunt is seen.
Patients show a "boot-shaped" heart on X-ray due to RVH.
Often patients, especially children, squat to alleviate cyanotic tet spells. This is a therapeutic action because squatting increases systemic resistance. The increase in systemic resistance allows more blood to be pumped into the pulmonary system and for improved oxygenation.
The only definitive treatment for TOF is surgical correction of the respective heart malformations.
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