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DOWNLOAD PDFTeriparatide is a recombinant PTH analog commonly used in the treatment of osteoporosis and specifically approved for use in those with glucocorticoid-induced osteoporosis.
Teriparatide works to increase osteoblastic activity, which leads to bone growth. This effect occurs when administered in a pulsatile fashion.
Teriparatide has a short duration of action and half-life, and, as such, the initial effect is bone resorption. This effect is then followed by an increase in bone formation. Thus, when administered in a pulsatile fashion, this stimulates bone formation compared to resorption and, over time, leads to increased bone density.
As a PTH analog, teriparatide is commonly used to treat osteoporosis. It is also approved for the treatment of glucocorticoid-induced osteoporosis and can be considered a first line in higher-risk patients.
Teriparatide should be used with caution in those with elevated risk factors for osteosarcoma. For instance, those with increased unexplained ALK-P, Paget disease of the bone, or those with a history of cancer or radiation therapy.
Teriparatide use can result in transitory hypercalcemia.
Teriparatide should be used with caution in those with elevated risk factors for osteosarcoma. For instance, those with increased unexplained ALK-P, Paget disease of the bone, or those with a history of cancer or radiation therapy.
Teriparatide should be used with caution in those with elevated risk factors for osteosarcoma. For instance, those with increased unexplained ALK-P, Paget disease of the bone, or those with a history of cancer or radiation therapy.
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