Master Pegloticase with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Pegloticase

Peg-cloth-in-case
DikeHAfifi
Pegloticase is a recombinant uricase that works by converting uric acid to allantoin. It used as 3rd line agent for chronic gout. Infusion reactions and gout flares are common side effects and pegloticase is contraindicated in patients with G6PD deficiency.
7 KEY FACTS
CHARACTERISTICS
Recombinant Uricase
Record-comb Unicorn-ace

Pegloticase is a recombinant uricase that works by converting uric acid to allantoin by an oxidation process.

Converts Uric Acid to Allantoin
Converting Unicorn Acidic-lemon to Alien-toe

By metabolizing uric acid to allantoin, which is water-soluble, serum uric acid decreases. Water-soluble metabolites are more easily eliminated by the kidney.

3rd Line Agent
3rd-place Agent with (3) Tree

The American College of Rheumatology recommends using pegloticase as a third-line agent for chronic gout. This means that patients must fail to respond to xanthine oxidase inhibitors (e.g. allopurinol) and uricosuric drugs (e.g. probenecid) before pegloticase can be considered.

INDICATIONS
Chronic Gout
Crone Goat

Pegloticase is indicated for chronic gout that does not improve with xanthine oxidase inhibitors or uricosuric medications. It is also indicated for rapid relief of symptoms or to reduce tophus quickly.

CONSIDERATIONS
Infusion Reactions
In-fused-IV Reaction

Infusion reactions is the second most common side effect of pegloticase. This happens a few hours after or during administration. Symptoms that can occur are urticaria, erythema, flushing, musculoskeletal pain, dyspnea, nausea/vomiting, headache, and changes in blood pressure. To prevent this event, the patient should be premedicated with antihistamines and corticosteroids.

Contraindicated in G6PD Deficiency
Caution-tape and (Gluco) glue (6) sax P (dehydrogenase) dehydrator (deficiency) broken

Pegloticase is contraindicated in patiehts with glucose-6-phosphate dehydrogenase (G6PD) deficiency. This is because pegloticase can precipitate a hemolytic crisis from the hydrogen peroxide produced when uric acid is converted to allantoin.

Gout Flares
Caution-tap on Goat with Flare-gun

The most common side effect of pegloticase is a gout flare. This is due to rapid decrease in serum uric acid levels and monosodium urate dissolution. It occurs in 80% of patients within the first 3 months of treatment.

Unlock all 7 facts & definitions with Picmonic Free!

Take the Pegloticase Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,240,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.