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Selective α₂ blockers are a class of drug which includes mirtazapine. This medication is indicated for depression treatment, though it has many off-label uses. It works by selectively blocking α₂ receptors, and having antagonist activity at 5-HT receptors, as well as other receptors. Mirtazapine has the side effects of sedation and increased serum cholesterol. A majority of patients develop weight gain while taking this drug as well.

7 KEY FACTS

Mirtazapine is an atypical antidepressant that blocks presynaptic α₂ receptors and also has serotonin 5-HT₂ and 5-HT₃ receptor antagonist activity.

Mirtazapine is indicated as a treatment for depression and other mood disorders.

This drug works by blocking α₂ agonists, which in turn leads to enhanced adrenergic and serotonergic transmission.

This drug is generally defined as a selective α₂ adrenergic receptor antagonist.

Sedation is a common side effect that may occur, possibly due to the blockade of 5-HT₂ and 5-HT₃receptors.

This drug is a potent stimulator of appetite and may cause weight gain, especially in younger patients.

Mirtazapine has been associated with increases in serum cholesterol and triglyceride levels.

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