Cystadenocarcinoma arise from ovarian surface epithelium and are either serous or mucinous.
Mucinous cystadenocarcinoma present with mucus-secreting epithelium and cysts containing these accumulated secretions.
Mucinous cystadenocarcinoma patients may experience pseudomyxoma peritonei, where mucinous material from the ovarian tumor accumulates within the peritoneal cavity.
Cystadenocarcinomas with serous lining comprise 45% of ovarian tumors and are often bilateral.
Serous cystadenocarcinoma tumors show papillary structures with round calcium deposits called psammoma bodies.
Tumors are often bilateral.
Cystadenocarcinoma is the most common malignant ovarian tumor.
Stromal invasion is often seen in cystadenocarcinoma, with tumors spreading past the basement membrane and into the stromal tissue.
Increased CA 125 is a common ovarian cancer marker. While not suitable for screening, it is effective for monitoring progression.
BRCA-1 and Lynch syndrome are hereditary risk factors for cystadenocarcinoma. BRCA-1 is more associated with serous cystadenocarcinoma.
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