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DOWNLOAD PDFNon-Hodgkinâs lymphoma is a lymphatic cancer, meaning that the cancerous cells originate in white blood cells (lymphocytes) in lymphoid tissue throughout the body. The lymphocytes in various stages of development may mimic a leukemia. The term non-Hodgkinâs lymphoma includes all lymph node cancers that do not have Reed-Sternberg cells.
Cancerous lymph nodes are non-contiguous in non-Hodgkin lymphoma, meaning that they are not next to each other.
Non-Hodgkinâs lymphoma can be classified according to the cells from which it originates, such as B and/or T cells. Other categories of classification include level of differentiation and rate of cell growth/division.
Patients with non-Hodgkinâs lymphoma may experience lymphadenopathy or swelling of the lymph nodes. The enlarged lymph nodes are painless and may be made worse by drinking alcohol.
The term âB symptomsâ refers to a group of symptoms, usually indicating a poor prognosis. These constitutional symptoms may also be the first sign of disease in patients.
Night sweats are another example of a B symptom, usually indicating a poor prognosis.
Fever is classified as a B symptom, and typically indicates that the patient has a high-grade lymphoma.
Weight loss is also classified as a B symptom, indicating an advanced stage of the disease.
In patients with an aggressive form of non-Hodgkinâs lymphoma, mediastinal or abdominal masses may be present.
Non-Hodgkinâs lymphoma tends to be more common in men, especially those over the age of 50.
There are more than 60 different subtypes of non-Hodgkinâs lymphoma.
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