IL-12 is responsible for the differentiation of T-cells into Th1 cells and is secreted by macrophages in the immune response.
IL-12 is responsible for the differentiation of T-cells into Th1 cells. This is an essential piece to the cell mediated response.
IFN-gamma is a key initiator for the Th1 cellular response, which is secreted after activation by IL-12, and mounts a strong response. Due to the limitations with IL-12, the IFN-gamma is in short supply and the immune response is decreased.
The Th1 response is responsible for cellular immunity, which is particularly essential for the immune response against mycobacterial pathogens.
Host defense against salmonella also depends heavily upon the functional integrity of mononuclear phagocytes and their interaction with T-cells.
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