summer slump sale Save up to 40% today
Medicine (MD/DO)
Hypothalamic & Pituitary Disorders
Sheehan's Syndrome

Master Sheehan's Syndrome with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Sheehan's Syndrome

Recommended Picmonics

picmonic thumbnail
Syndrome Of Inappropriate Antidiuretic Hormone (SIADH)
picmonic thumbnail
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Nonpharmacologic Interventions
picmonic thumbnail
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Pharmacologic Interventions
picmonic thumbnail
Acromegaly Assessment
picmonic thumbnail
Primary Polydipsia

Sheehan's Syndrome

Sheehan's syndrome can be described as hypopituitarism caused by pituitary necrosis. This pituitary necrosis occurs due to blood loss and hypovolemic shock associated with postpartum bleeding. Patients with Sheehan's syndrome commonly present with agalactorrhea and amenorrhea and can also suffer from cold intolerance due to secondary hypothyroidism.
Postpartum Pituitary Gland Necrosis
Post-baby giving Pit-bull-terrier to Necrosis-crow

Patients with Sheehan's syndrome typically present with postpartum agalactorrhea (absence of lactation) and sometimes amenorrhea. As a result of postpartum hemorrhage, ischemic pituitary necrosis occurs, and hormone secretion from the anterior pituitary is usually interrupted. Typically patients lose prolactin (PRL), growth hormone (GH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), and/or thyroid stimulating hormone (TSH) secretion. Occasionally, secretion of the posterior pituitary hormones oxytocin (OXT) and antidiuretic hormone/arginine vasopressin (ADH/AVP) can also be disrupted.


As patients develop hypopituitarism in Sheehan’s syndrome, one of the most common initial symptoms is agalactorrhea when attempting to breastfeed. This symptom occurs because of the loss of prolactin, which is responsible for regulating milk production during the postpartum period.


Commonly, women with Sheehan's syndrome also complain of amenorrhea or oligomenorrhea. This disruption in normal menstruation occurs due to a loss of gonadotropins like FSH and LH.

Secondary Hypothyroidism with Cold Intolerance
(2) Tutu Hippo-thigh-droid and Ice-cube Shivering

Hypopituitarism in Sheehan's syndrome can lead to decreased TSH secretion, yielding a lack of thyroid hormones. Without TSH, the thyroid gland cannot be stimulated, resulting in a decreased release of triiodothyronine (T3) and thyroxine (T4). Thus, Sheehan's syndrome can lead to a form of secondary (2º) hypothyroidism. Patients often complain of cold intolerance.


Take the Sheehan's Syndrome Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,900,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.