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Hypercholesterolemia Risk Stratification

Hypercholesterolemia Risk Stratification

Hiker-cholesterol-burger Risk Layers

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In order to properly treat patients with hypercholesterolemia, one must take into account a patient’s serum LDL levels in conjunction with their risk factors and 10-year risk of having a coronary heart disease (CHD)-related event, such as a myocardial infarction. The higher the number of risk factors a patient has, the lower their target LDL level must be to prevent future adverse events. Doctors may suggest lifestyle modifications or pharmacotherapy to lower LDL levels and a patient’s risk of CHD-related events.

6 KEY FACTS

In patients with 0-1 risk factors for coronary heart disease or in those with a calculated risk 10-year risk of CHD-related events <10%, target LDL is < 160 mg/dL.

Lifestyle modifications are recommended for those with LDL between 160 and 190 mg/dL; pharmacotherapy should be recommended in this population once LDL>190 mg/dL.

In patients with 2 or more risk factors for coronary heart disease or in those with a calculated 10-year risk of CHD-related events between 10 and 20%, target LDL is < 130 mg/dL.

Pharmacotherapy is recommended in this population to achieve the LDL goal of <130 mg/dL.

For patients with coronary heart disease or a risk-equivalent condition (peripheral vascular disease, diabetes mellitus, aortic stenosis, etc.) or 2 or more risk factors and a calculated 10-year risk of CHD-related events >20%, target LDL is < 100 mg/dL.

Pharmacotherapy is necessary in this population to achieve the LDL goal of <100 mg/dL.

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