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Pseudogout

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Pseudogout is the deposition of calcium pyrophosphate crystals in joints, which are positively birefringent. Patients complain of arthritis, typically in the knee, and are usually above 50 years of age.

8 KEY FACTS

This disease is more common with age and is typically seen in individuals above the age of 50 years old.

Pseudogout can be monoarticular or polyarticular. It classically manifests as large joint pain, particularly affecting the knee.

Calcium pyrophosphate crystals accumulate in joint causing arthritis. It is unknown how these crystals form.

These crystals are positively birefringent under polarized light. Thus, they appear blue when parallel to the light.

This refers to calcification of articular cartilage and can be seen on imaging.

NSAIDs help relieve pain and inflammation in patients with pseudogout.

Colchicine can inhibit leukocyte chemotaxis and degranulation and thus reduce inflammation and associated pain.

Steroids can reduce inflammation and associated pain.

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