High fever is a common symptom of Legionnaires' disease.
Diarrhea is commonly seen in Legionnaires' disease.
Laboratory tests often demonstrate increased liver enzymes in Legionnaire's disease.
Hyponatremia is a common finding on laboratory tests, often as a result of kidney derangements.
Type IV renal tubular acidosis is often caused by an aldosterone deficiency or resistance. Legionella can produce interstitial kidney disease that destroys the juxtaglomerular apparatus, decreasing the ability to secrete renin. Due to a decrease in renin, there is an aldosterone deficiency, leading to Type IV renal tubular acidosis.
Legionnaires' disease causes severe atypical pneumonia with bi-basal consolidation.
Pontiac fever is also caused by this organism but produces a milder respiratory illness without pneumonia. Clinical presentation of Pontiac fever typically resembles acute influenza.
Fluoroquinolones are a family of broad-spectrum antibiotic drugs that commonly end with the suffix “floxacin,” like ciprofloxacin and moxifloxacin. These drugs are bactericidal and eradicate bacteria by interfering with DNA replication. Fluoroquinolones can be used in the treatment of Legionella.
Macrolides are a group of antibiotics whose activity stems from the presence of a macrolide lactone ring. Commonly used macrolides include erythromycin, azithromycin, and clarithromycin. As a class, these drugs bind to the 23S rRNA of the 50S prokaryotic ribosomal subunit and inhibit protein synthesis via the blocking of translocation. They can be used in the treatment of Legionella.
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