Cidofovir is used to treat cytomegalovirus (CMV) retinitis in patients who are immunocompromised.
Cidofovir has been shown to be effective when treating patients with acyclovir-resistant herpes-simplex virus (HSV) infections.
Cidofovir inhibits viral replication by selectively inhibiting viral DNA polymerases. Thus, this drug inhibits viral DNA synthesis during its reproduction cycle.
The major side effect of this medication is nephrotoxicity, which is dose-dependant.
Coadministering probenecid and IV saline with cidofovir decreases the nephrotoxic effects in patients.
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