Amphotericin B and Side Effects Mnemonic Video

Amphotericin B is used to treat various systemic fungal infections. Examples include patients who are critically ill, comorbidly infected, or immunocompromised with suspected Cryptococcus.

Amphotericin B is used to treat fungal meningitis, such as cryptococcal meningitis.

Amphotericin B can also be used intravenously to treat otherwise-untreatable parasitic protozoan infections like visceral leishmaniasis and amoebic meningoencephalitis from Naegleria Fowleri.

This medication works as a polyene as it binds to ergosterol and forms membrane pores.

After binding to ergosterol, Amphotericin B forms membrane pores and allows leakage of electrolytes, resulting in fungal cell death.

After binding to ergosterol, Amphotericin B forms membrane pores, which allows leakage of electrolytes, ultimately killing the fungal cell.