Master Amphotericin B with Picmonic for Medicine

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Amphotericin B is a polyene medication, which works by binding to ergosterol in fungal cell membranes. It forms membrane pores, causing electrolytes to leak, killing the fungal cell. It is used for serious, systemic mycoses. It can lead to the side effects of fever and chills, nephrotoxicity, arrhythmias, anemia and IV phlebitis.

6 KEY FACTS

Amphotericin B is used to treat various systemic fungal infections. Examples include patients who are critically ill, comorbidly infected, or immunocompromised, who may have cryptococcus.

Amphotericin B is used to treat fungal meningitis, such as cryptococcal meningitis.

Amphotericin B can also be used intravenously to treat otherwise-untreatable parasitic protozoan infections, with examples such as visceral leishmaniasis and amoebic meningoencephalitis from Naegleria Fowleri.

This medication works as a polyene, meaning that it binds to ergosterol and forms membrane pores.

Amphotericin B binds to ergosterol, which is a component of fungal cell membranes.

After binding to ergosterol, Amphotericin B forms membrane pores, which allows leakage of electrolytes, ultimately killing the fungal cell.

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