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Amphotericin B Side Effects & Toxicity

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Amphotericin B

Amphibian-terminator (B) Bee

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Amphotericin B is a polyene medication, which works by binding to ergosterol in fungal cell membranes. It forms membrane pores, causing electrolytes to leak, killing the fungal cell. It is used for serious, systemic mycoses. It can lead to the side effects of fever and chills, nephrotoxicity, arrhythmias, anemia and IV phlebitis.

6 KEY FACTS

Amphotericin B is used to treat various systemic fungal infections. Examples include patients who are critically ill, comorbidly infected, or immunocompromised, who may have cryptococcus.

Amphotericin B is used to treat fungal meningitis, such as cryptococcal meningitis.

Amphotericin B can also be used intravenously to treat otherwise-untreatable parasitic protozoan infections, with examples such as visceral leishmaniasis and amoebic meningoencephalitis from Naegleria Fowleri.

This medication works as a polyene, meaning that it binds to ergosterol and forms membrane pores.

Amphotericin B binds to ergosterol, which is a component of fungal cell membranes.

After binding to ergosterol, Amphotericin B forms membrane pores, which allows leakage of electrolytes, ultimately killing the fungal cell.

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Master Amphotericin B with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Amphotericin B

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Picmonic for Medicine Covers

Our Story Mnemonics Increase Mastery and Retention

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,210,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

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