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Amphotericin B
Systemic Mic-fungus
Amphotericin B is used to treat various systemic fungal infections. Examples include patients who are critically ill, comorbidly infected, or immunocompromised, who may have cryptococcus.
Fun-guy Men-in-tights
Amphotericin B is used to treat fungal meningitis, such as cryptococcal meningitis.
Last Resort Propeller-protozoa
Amphotericin B can also be used intravenously to treat otherwise-untreatable parasitic protozoan infections, with examples such as visceral leishmaniasis and amoebic meningoencephalitis from Naegleria Fowleri.
Polly-lean
This medication works as a polyene, meaning that it binds to ergosterol and forms membrane pores.
Binding to Eggo-stairs
Amphotericin B binds to ergosterol, which is a component of fungal cell membranes.
Membrane Holes
After binding to ergosterol, Amphotericin B forms membrane pores, which allows leakage of electrolytes, ultimately killing the fungal cell.
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