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Medicine (MD/DO)
5th Generation Cephalosporin

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5th Generation Cephalosporin

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5th Generation Cephalosporin

(5) Hand Chef-spore-head
Fifth generation cephalosporins are broad spectrum antibiotics which are beta-lactams. These antibiotics were specifically created in labs to target resistant organisms, such as methicillin-resistant Staph aureus (MRSA).

Cephalosporins are beta-lactam antibiotics and have a beta-lactam ring in their structure, working to inhibit bacterial cell wall biosynthesis.

Resistant Bacteria
Resistance-bandana Bacteria-guy

Fifth-generation cephalosporins are indicated for treating bacteria that are otherwise resistant to other commonly used antibiotics. One example of this drug's effectiveness is against MRSA.

Broad Spectrum Gram-Positive and Gram-Negative
Broad Spectrum-of-colors with Gram Positive-angel and Gram Negative-devil

This drug class has a broad spectrum of applicability and inhibits the growth of a wide variety of gram-positive and gram-negative bacteria.


This drug has been called a 5th-generation cephalosporin, but the terminology is not universally accepted. This drug has powerful antipseudomonal activity and binds strongly to penicillin-binding protein 2a. It has activity against MRSA, Streptococcus pneumoniae, and enterococci as well.

Has Pseudomonas Coverage
Sumo-Mona Covered

Ceftobiprole is a newer medication used for healthcare-associated pneumonia (HCAP), which has powerful antipseudomonal coverage. Additionally, this drug also covers MRSA strains which are less susceptible to daptomycin, vancomycin, or linezolid.


Ceftaroline has broad-spectrum activity against many gram-positive organisms, such as MRSA, MRSE, and VRE. It does not have great coverage of beta-lactam gram-negative bacteria, such as bacteroides.

No Pseudomonas Coverage
No-sign Sumo-Mona

It should be noted that, unlike 3rd and 4th-generation cephalosporins, 5th-generation cephalosporins are not effective against Pseudomonas infections.


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