Cephalosporins are beta-lactam antibiotics, and have a beta-lactam ring in their structure, working to inhibit bacterial cell wall biosynthesis.
Fifth generation cephalosporins are indicated for treating bacteria, which are otherwise resistant to other commonly used antibiotics. An example which this drug class is effective against includes MRSA.
This drug class has a broad spectrum of applicability and inhibit growth of a wide variety of gram-positive and gram-negative bacteria.
This drug has been called a 5th generation cephalosporin, but the terminology is not universally accepted. This drug has powerful antipseudomonal activity, and binds strongly to penicillin-binding-protein 2a. It has activity against MRSA, Streptococcus pneumoniae, and enterococci as well.
Ceftobiprole is a newer medication used for healthcare-associated pneumonia (HCAP), which has powerful antipseudomonal coverage. Additionally, this drug also has MRSA strains which are less susceptible to daptomycin, vancomycin or linezolid.
Ceftaroline has broad spectrum activity against many gram-positive organisms, such as MRSA, MRSE, and VRE. It does not have great coverage of beta-lactam gram-negative bacteria, such as bacteroides.
It should be noted that unlike 3rd and 4th generation cephalosporins, this particular 5th generation cephalosporin is not effective against Pseudomonas infections.
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