Master MEN 1 (Multiple Endocrine Neoplasia) with Picmonic for Medicine

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Man with (1) Wand

Picmonic

Multiple endocrine neoplasm type one is a group of neoplasms occurring together due to a specific gene mutation. This gene mutation is inherited in an autosomal dominant fashion which results in characteristic patient presentations. In MEN I, the neoplasms typically originate from the pancreas, the parathyroid gland, and the pituitary gland. Tumors in the pancreas include several tumor types including gastrinomas, insulinomas, VIPomas, and glucagonomas. Excess parathyroid hormone can present as hypercalcemia and pituitary tumors often produce prolactin or growth hormone.

6 KEY FACTS

This disease is inherited in an autosomal dominant fashion.

Menin is coded by the MEN 1 gene and is a tumor suppressor gene. This mutation on chromosome 11 leads to tumor growth.

This mutation on chromosome 11 leads to MEN 1 syndrome.

Tumors of the pancreas, as well as the duodenum, are one of the culprits of MEN1. There are several types of tumors in the pancreas, including gastrinomas, insulinomas, VIPomas, and glucagonomas. Depending on the type of pancreatic tumor, patients can present in a variety of ways, including ulcers, hypoglycemia, or hyperglycemia.

Pituitary tumors are characteristic of MEN1 and are most commonly prolactinomas. Growth hormone tumors can also occur. Enlargement of a pituitary tumor can compress the optic chiasm, causing bitemporal hemianopia.

Parathyroid tumors are characteristically involved with MEN1 and present as hypercalcemia. Many times, patients will present with kidney stones as a consequence of prolonged hypercalcemia.

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