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Anticentromere Antibodies

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Anticentromere Antibodies

Anti-cent-mirror Ant-tie-body
Anticentromere antibodies are antibodies directed against centromeric proteins. They are present in various autoimmune disorders but are most commonly seen in CREST. They are sometimes also seen in diffuse scleroderma.
Autoimmune Disorders

Anticentromere antibodies are present in various autoimmune disorders, especially in CREST.

CREST Syndrome (Limited Scleroderma)

Anticentromere antibodies are found in 90% of patients with CREST syndrome, which is now known as limited or localized scleroderma. It is characterized by calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia.

Diffuse Scleroderma
D-fuse Skull-arrow-deer

Anticentromere antibodies are found in 15% of those with the diffuse form of scleroderma. Anti-Scl 70 antibodies (antibodies directed against DNA topoisomerase) are more commonly found in these patients.


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