NutraSweet is an additive high in phenylalanine, and a lack of a proper diet during pregnancy can cause symptoms in the developing fetus. For women with phenylketonuria, it is important for the health of their children to have low phenylalanine levels before and during pregnancy, because high levels of phenylalanine can cross the placenta and affect the developing fetus.
Excess phenylalanine can disrupt cardiac development and cause congenital heart defects in the newborn.
Infants with maternal phenylketonuria fail to grow at an appropriate rate, and also fail to attain early developmental milestones.
Infants with maternal phenylketonuria can display severely impaired cognitive functioning with deficits in two or more adaptive behaviors.
A neurodevelopmental disorder in which the head circumference is more than two standard deviations smaller than the average circumference for the person's age and gender. It is a common clinical feature of infants with maternal phenylketonuria.
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