Master Carboprost (Hemabate) Nursing Considerations

Carboprost (Hemabate) is a synthetic analog of prostaglandin F2-alpha (PGF2α). It mimics the actions of the naturally occurring PGF2α by binding to the same receptors, which is why it is referred to as a prostaglandin analog.

Prostaglandins stimulate smooth muscle contraction, including in the uterus. Carboprost (Hemabate), a prostaglandin F2α analog, promotes intense uterine contractions, which help control postpartum hemorrhage by compressing uterine blood vessels and reducing bleeding.

After delivery of the infant and placenta, the uterus normally contracts to compress blood vessels and minimize bleeding. When uterine contractions are inadequate, postpartum hemorrhage can occur. In such cases, carboprost (Hemabate) is administered to induce strong uterine contractions, helping to reduce bleeding and restore hemostasis.

Carboprost (Hemabate) may also be used to induce abortion during the second trimester, particularly in cases of intrauterine fetal demise or missed abortion, by stimulating strong uterine contractions.

Nausea, vomiting, and diarrhea are common side effects of carboprost, as prostaglandins stimulate smooth muscle contraction in the gastrointestinal tract, leading to increased motility and cramping.

Fever is a common side effect of carboprost, likely due to its prostaglandin activity on the hypothalamic thermoregulatory center. However, if a fever occurs postpartum, it's essential to evaluate the underlying cause to determine whether it's drug-induced or a sign of an underlying infection, such as endometritis.

The effects of prostaglandins on blood vessels vary by type and tissue, with some leading to vasodilation and others causing vasoconstriction. Carboprost can induce transient increases in blood pressure, possibly due to increased systemic vascular resistance or a stress response to pain or uterine contractions. It is generally moderate and does not require treatment

As a uterotonic agent, it causes strong uterine contractions, which may be painful or uncomfortable, especially in non-laboring patients.

Carboprost is a prostaglandin F2α analog, which stimulates smooth muscle contraction, including bronchial smooth muscle. This can lead to bronchospasm, making it dangerous for patients with asthma or other reactive airway diseases.

Fever is a common side effect of carboprost. If a fever develops, the cause of the fever must be identified to determine whether it is drug-induced or due to another condition/infection, such as endometritis. Failure to recognize postpartum or post-abortion endometritis may lead to sepsis and death.

Carboprost is a prostaglandin F2α analog that can stimulate bronchial smooth muscle contraction, potentially triggering severe bronchospasm in patients with asthma or other reactive airway diseases.