Carboprost (Hemabate) is a synthetic prostaglandin, similar to the naturally occurring F2-alpha prostaglandin. Because of its similar structure, it is called an analog.
Prostaglandins cause contraction of smooth muscle. In this case, carboprost (Hemabate) works by causing intense uterine contractions to stop postpartum bleeding.
Typically, after a woman delivers the infant and the placenta, the uterus continues to contract and bleeding stops. When this doesn’t happen, postpartum hemorrhage can occur. Carboprost (Hemabate) is given to induce intense uterine contractions, in order to stop postpartum bleeding.
Carboprost (Hemabate) may also be used to induce abortion in the second trimester of pregnancy by generating strong uterine contractions. Other off-label uses for this medication include treatment of hemorrhagic cystitis.
Nausea, vomiting, and diarrhea are common, as prostaglandins stimulate the smooth muscle tissue in the stomach and intestines.
Prostaglandins cause vasoconstriction, which may lead to hypertension. Carboprost should be used with caution in patients with a history of high blood pressure.
Fever is a common side effect associated with the medication. If a fever develops, the cause of the fever must be identified to determine whether it is drug-induced or due to another condition/infection, such as endometritis.
Prostaglandins can cause bronchoconstriction and should be used with caution in patients with a history of asthma.
Fever is a common side effect of carboprost. If a fever develops, the cause of the fever must be identified to determine whether it is drug-induced or due to another condition/infection, such as endometritis. Failure to recognize postpartum or post-abortion endometritis may lead to sepsis and death.
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