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Carboprost (Hemabate)

Car-bow-priest
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Carboprost (Hemabate) is a synthetic prostaglandin used to treat postpartum hemorrhage by inducing uterine contractions. Typically, after a woman gives birth, the uterus continues to contract and bleeding stops. Postpartum hemorrhage can occur when this doesn't happen, however. Carboprost can also be used to induce abortion in the second trimester of pregnancy. Side effects of carboprost (Hemabate) include: hypertension, fever, bronchoconstriction, nausea, vomiting, and diarrhea. If the patient develops a fever, the cause of the fever must be identified, to determine whether the fever is drug-induced, or due to another condition such as endometritis.
9 KEY FACTS
MECHANISM
Prostaglandin F2-alpha Analog
P-rasta and Fox in (2) Tutu with Afro On-a-log

Carboprost (Hemabate) is a synthetic prostaglandin, similar to the naturally occurring F2-alpha prostaglandin. Because of its similar structure, it is called an analog.

Smooth Muscle Contraction
Smoothie Muscle Flexing

Prostaglandins cause contraction of smooth muscle. In this case, carboprost (Hemabate) works by causing intense uterine contractions to stop postpartum bleeding.

INDICATIONS
Postpartum Hemorrhage
Post-baby with Hemorrhage-hammer

Typically, after a woman delivers the infant and the placenta, the uterus continues to contract and bleeding stops. When this doesn’t happen, postpartum hemorrhage can occur. Carboprost (Hemabate) is given to induce intense uterine contractions, in order to stop postpartum bleeding.

Abortion
Aborting Fetus

Carboprost (Hemabate) may also be used to induce abortion in the second trimester of pregnancy by generating strong uterine contractions. Other off-label uses for this medication include treatment of hemorrhagic cystitis.

SIDE EFFECTS
GI Distress
GI shooting Flare-gun

Nausea, vomiting, and diarrhea are common, as prostaglandins stimulate the smooth muscle tissue in the stomach and intestines.

Hypertension
Hiker-BP

Prostaglandins cause vasoconstriction, which may lead to hypertension. Carboprost should be used with caution in patients with a history of high blood pressure.

Fever
Fever-beaver

Fever is a common side effect associated with the medication. If a fever develops, the cause of the fever must be identified to determine whether it is drug-induced or due to another condition/infection, such as endometriosis.

Bronchoconstriction
Broccoli-constrictor

Prostaglandins can cause bronchoconstriction and should be used with caution in patients with a history of asthma.

CONSIDERATIONS
Identify Cause of Fever
ID Fever-beaver

Fever is a common side effect of carboprost. If a fever develops, the cause of the fever must be identified to determine whether it is drug-induced or due to another condition/infection, such as endometritis. Failure to recognize postpartum or post-abortion endometritis may lead to sepsis and death.

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