Highly specific tests rarely miss negative outcomes so they can be considered reliable when their test is positive. Therefore, tests with high specificity are often used to "rule in" disease and can be remembered by the word SPIN for specificity rules in.
Because there are few false positives in diseases with high specificity, they are often used as confirmatory tests for the presence of disease.
The formula for specificity equals the number of true negatives divided by (true negatives plus false positives).
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