The antidote for antimuscarinic toxicity is physostigmine salicylate. Physostigmine is the only reversible acetylcholinesterase inhibitor capable of directly antagonizing the CNS manifestations of anticholinergic toxicity because it is an uncharged tertiary amine that can efficiently cross the blood-brain barrier. By inhibiting acetylcholinesterase, there is an increased concentration of acetylcholine which augments stimulation at muscarinic receptors.
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