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Levothyroxine

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Levothyroxine is synthetic T4 that is converted to T3 by 5’deiodinase in peripheral tissues. T3 and to a smaller degree, T4, then bind to thyroid hormone nuclear receptors in target cells to exert their effects.

5 KEY FACTS

Levothyroxine is used to treat hypothyroidism with the average replacement dose in adults being 1.6 mcg/kg body weight per day.

This is a severe hypothyroid state that is treated with Levothyroxine, supportive measures and management of infection.

Like endogenous T4, Levothyroxine is converted into T3 via the 5’deiodinase enzyme. The T3 binds to thyroid hormone nuclear receptors and results in various functions such as brain maturation, bone growth, beta-adrenergic effects, and increased basal metabolic rate.

Levothyroxine is converted into T3, which has 10X greater affinity than T4 for thyroid hormone nuclear receptors. Effects at these receptors lead to brain maturation, bone growth, beta-adrenergic effects, and increased basal metabolic rate.

Too much Levothyroxine can result in hyperthyroid symptoms, such as tachycardia, heat intolerance, tremors and arrhythmias.

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