Memantine is an NMDA receptor antagonist drug which helps prevent excitotoxicity in patients with Alzheimer's.
Memantine is a glutamatergic antagonist at NMDA receptors. This action allows to impede an influx of Ca2+, halting excitotoxicity to neurons. This drug is low affinity and short-acting with a modest effect.
By antagonizing NMDA receptors, excitotoxicity is prevented in neurons. Excitotoxicity is mediated by Ca2+ which activates intracellular enzymes, leading to cell destruction.
An adverse effect of treatment with memantine is confusion in patients.
Patients taking memantine can suffer from hallucinations.
Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.START QUIZ NOW
*Average video play time: 2-3 minutes
Unforgettable characters with concise but impactful videos (2-4 min each)