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Ezetimibe

A-Zitty-Tribe

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Ezetimibe is used to lower plasma cholesterol in patients with hyperlipidemia by preventing cholesterol reabsorption at the small intestine brush border. As a consequence of blocking cholesterol absorption, LDL receptors are upregulated, causing increased LDL uptake into cells. Thus, there is a lower LDL value in circulating blood. A common side effect of this medication is diarrhea, which occurs as a result of large amounts of cholesterol being trapped in the gut lumen. A rare side effect of Ezetimibe treatment is increased LFT values.

5 KEY FACTS

This drug is indicated for hyperlipidemia, which refers to abnormally high levels of lipids or lipoproteins in the blood.

Ezetimibe is a cholesterol absorption blocker that targets Niemann-Pick C1-Like 1 (NPC1L1), a sterol transporter, resulting in decreased uptake of cholesterol at the brush border of the small-intestine. They are especially effective when combined with statins, another class of drugs used to treat hyperlipidemia.

Ezetimibe decreases cholesterol absorption, which leads to LDL receptor upregulation. This results in increased uptake of LDL into cells, and decreased levels in the blood.

A side effect of Ezetimibe is diarrhea, as inhibition of cholesterol absorption keeps cholesterol in the intestinal lumen to be excreted.

Liver function tests are a set of laboratory blood tests meant to assess the state of a patient's liver. Those taking Ezetimibe are cautioned to monitor liver function tests (LFT), although increased LFT values are a very rare side effect.

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