CNS stimulant drugs are primarily used to treat ADHD or ADD. This is typically prescribed to help increase concentration and focus while at school or work.
Obese patients may often be prescribed CNS stimulants, as these medications can be used to promote weight loss. This is because CNS stimulants decrease appetite in patients.
The main mechanism by which amphetamines cause stimulation is via the direct release of catecholamines from storage vesicles in presynaptic cells, leading to increased NE and dopamine. Another, minor, mechanism by which these drugs increase NE and dopamine bioavailability is by inhibiting their reuptake.
These drugs cause stimulatory effects in the patient by increasing presynaptic vesicle release of catecholamines, one of them being NE.
These drugs increase dopamine by inducing the release of catecholamine-containing storage vesicles. Dopamine's bioavailability is also increased by blocking its reuptake with these drugs.
Methylphenidate is a commonly prescribed drug used to treat ADHD and ADD, and is for improving concentration and focus. Off label uses include combating obesity, lethargy and depression.
Methamphetamine is a controlled CNS stimulant medication used to treat obesity. Off label uses of this drug include narcolepsy and depression.
These drugs are often abused for recreational use and can be highly addictive.
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