Chlorpromazine is a low potency antipsychotic which is used with psychosis, schizophrenia and manic episodes. This drug has the side effect of hypotension and also has anti-histamine properties, which counteract the extrapyramidal symptoms experienced with antipsychotics.
Chlorpromazine is accumulated in the corneal stroma of the eye. After light exposure, cellular damage occurs, as the drug is a phototoxic compound. This may lead to color-blindness and benign pigmentation of the cornea.
Thioridazine is an antipsychotic medication typically used to treat schizophrenia and psychosis. It is a low potency antipsychotic and has very serious adverse effects. This drug can lead to extrapyramidal symptoms, neuroleptic malignant syndrome, impotence and autonomic side effects.
Thioridazine can lead to retinal deposits in patients.
The α1 antagonist effects of these medications may lead to hypotension, and rarely, impotence or anorgasmia.
Anti-cholinergic effects, such as dry mouth, urination difficulty, obstipation, induction of glaucoma, postural hypotension, and sinus tachycardia may occur. However, these are seen less often than with most other mildly potent antipsychotics.
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