This drug is an anticonvulsant agent indicated for partial seizures and severe tonic-clonic (grand mal) seizures.
Migraine headache prophylaxis is the most prescribed use of Topiramate, due to its effects on blood vessels in the brain.
While the exact mechanism is still unclear, it is thought that topiramate acts to potentiate GABA action.
The exact mechanism of Topiramate is still unclear, although it is thought that its antiepileptic and antimigraine effects may be partially due to a blockage of voltage-gated sodium channels.
Kidney stones may occur as a side effect of Topiramate use.
An adverse side effect of Topiramate is weight loss. Recently, however, this drug has been FDA approved to be used for weight loss in obesity when combined with phentermine.
The side effect of topiramate most-frequently leading to discontinuation is sedation.
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