Bowenoid papulosis is the transitional stage between genital warts and Bowen disease.
Bowenoid papulosis is commonly associated with HPV 16.
Bowenoid papulosis presents with multiple, flat reddish-brownish papules on the external genitalia (particularly the shaft, glans, foreskin, and perianal region).
Treatment of bowenoid papulosis involves re-examination every 3-6 months as the lesions often regress spontaneously. If the lesions are persistent, then local destruction therapy followed by surveillance (annual exams) is recommended as lesions may recur.
Bowen disease is a squamous cell carcinoma in situ of the penile skin. It typically impacts non-mucosal skin (vs. erythroplasia of Queyrat, which affects mucous membranes) anywhere on the body, including the penis.
Bowen disease is associated with HPV strains 16 and 18.
Bowen disease commonly occurs on skin that is either exposed to the Sun or arsenic, as these risk factors are associated with metaplasia and dysplasia.
Leukoplakia can be described as persistent white plaques that cannot be scraped off. The lesions can be irregularly shaped with sharply defined borders. Erythematous and scaly skin is often adjacent to these lesions.
Bowen disease along with erythroplasia of Queyrat can be treated with pharmacotherapy (e.g. 5-FU, imiquimod), photodynamic therapy, and surgical excision with margins.
Erythroplasia of Queyrat is squamous cell carcinoma in situ of the penile mucosa. It commonly affects the prepuce and glans penis.
Erythroplasia of Queyrat is associated with HPV strains 16 and 18.
A lack of circumcision along with chronic irritation or infection is associated with erythroplasia of Queyrat.
Erythroplasia of Queyrat presents with erythroplakia as single or multiple sharply demarcated, non-healing lesions (e.g. plaques or red papules). These lesions may ulcerate and bleed easily.
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