Beat The Heat SAVE 25% NOW
Medicine (MD/DO)
Other Hematologic Pathology
Essential Thrombocythemia

Master Essential Thrombocythemia with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Essential Thrombocythemia

Recommended Picmonics

picmonic thumbnail
Primary Myelofibrosis
picmonic thumbnail
Tumor Lysis Syndrome
picmonic thumbnail
Snake Bite Injury
picmonic thumbnail
Langerhans Cell Histiocytosis
picmonic thumbnail
Hemophagocytic Lymphohistiocytosis

Essential Thrombocythemia

Espresso Trombone-cyclist
Essential Thrombocythemia is caused by JAK2 mutations. It is often asymptomatic but can lead to thromboembolic events like spontaneous abortions, erythromelalgia, and gout. Diagnosis is made by isolated thrombocytosis on CBC and isolated megakaryocyte hyperplasia on bone marrow biopsy. Patients are often treated with prophylactic aspirin and hydroxyurea.
JAK2 Mutation
Jack in (2) Tutu Mutant

Janus Kinase 2 is an intracellular tyrosine kinase involved in cytokine-mediated signaling. Mutations in the JAK2 gene are associated with myeloproliferative disorders like polycythemia vera, primary myelofibrosis, and essential thrombocythemia.

Often Asymptomatic

Patients are usually asymptomatic for extended periods of time, and the disease may be discovered incidentally.

Thromboembolic Events
Trombone with Thromboembolic Event

Essential thrombocythemia can cause both micro- and macrovascular thrombosis. This can include transient ischemic attacks, deep vein thrombosis, erythromelalgia, and ocular migraine.

Spontaneous Abortion
Spartan Aborting-fetus

Abortion is an intrauterine death of the fetus before it attains viability. Due to the increased risk of thrombosis, there is a marked degree of uteroplacental insufficiency and thus, an increased risk of abortions.


Erythromelalgia is characterized by a triad of redness, warmth, and burning pain of hands and feet. It is due to the decreased caliber of blood vessels causing vascular compromise to muscles and nerves.


Due to the high cell turnover in essential thrombocythemia, serum uric acid is elevated which gets deposited in joints causing gouty arthritis.

Up-arrow Plate

Due to JAK2 mutation and increased megakaryocyte colony stimulating factors, platelet count is greater than 600,000/μL in this disease.

Megakaryocyte Hyperplasia
Up-arrow Mega-carrot and Hiker-plates

Giant mature megakaryocytes with multilobulated nuclei are present in clusters in the bone marrow. This occurs from increased production and growth of platelet precursors (megakaryocytes) because of the mutation.


Aspirin is an irreversible cyclooxygenase-1 inhibitor and is an antiplatelet drug. It is given for the prophylaxis of thrombotic events in mild cases.


Hydroxyurea is an anti-cancer drug that arrests cells in the S phase of the cell cycle by inhibiting ribonucleotide reductase. It is given to reduce platelet counts.


Take the Essential Thrombocythemia Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,910,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.