Don't let Zollinger-Ellison syndrome stump you. Picmonic uses a powerful ZES mnemonic to unlock key features like symptoms, treatments, and potential complications. Engaging characters, stories, and quizzes solidify your understanding of this gastrinoma-related condition. Master GI physiology and conquer your USMLE exams with Picmonic!
DOWNLOAD PDFNormal gastrin levels in healthy patients rarely exceed 100pg/mL. Patients with Zollinger-Ellison syndrome (ZES) have fasting serum gastrin levels that exceed this, and often go beyond 1000 pg/dL. If gastrin levels are found to be this high, it is diagnostic of ZE syndrome. Another, rather sensitive and specific, diagnostic method is to measure basal gastric acid output, or to measure gastric pH. Aberrantly high levels of gastric acid output, or an extremely low pH.
The secretin stimulation test is the most specific and sensitive test for identifying gastrinomas causative of Zollinger-Ellison syndrome (ZES). The secretin stimulation test is considered a provocative test, as the response to administered secretin is measured, and the patientâs response aids in diagnosis. In this test, secretin is administered as a bolus after an overnight fast, and gastrin levels are measured in response at different time intervals. An increase in serum gastrin of greater than 200 pg/mL yields a positive test result and is diagnostic of ZES.
High-dose proton pump inhibitors (PPIs) are used to slow down acid secretion by parietal cells in Zollinger-Ellison syndrome (ZES), and are considered a first-line therapy. Extended use of these medications in older patients, however, is linked to an increased risk of fracture. It should be noted PPI use is not curative, but alleviates the complications of excess acid secretion in patients (GERD, heartburn, abdominal pain, ulcer formation).
Octreotide is a somatostatin analog that is used as a second-line agent in treating Zollinger-Ellison syndrome (ZES). This medication is very effective in treating VIPomas, carcinoid tumors and glucagonomas, but has unpredictable results with the gastrinomas seen with ZES. Despite its unpredictability, this drug can reduce gastrin levels and may slow tumor growth, and can be used in patients who have unsuccessful results with high-dose proton pump inhibitors.
Surgery is the only modality of treatment which may lead to a cure. This, however, is hinged on the tumor being in a resectable area and non-metastatic. All sporadic cases of Zollinger-Ellison syndrome (ZES) should be surgically explored (including duodenotomy) even with negative imaging results, because of the high likelihood of finding and removing a tumor for potential cure. Surgery for multiple endocrine neoplasia type 1 (MEN 1) related cases should be focused on prevention of metastatic disease, with surgery being recommended when pancreatic tumors are greater than 2 cm.
Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.
*Average video play time: 2-3 minutes
Unforgettable characters with concise but impactful videos (2-4 min each)
Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether youâre studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, weâre here to help.
Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.