This syndrome occurs when there are bilateral amygdala lesions. Patients who have had lobectomies, tumors, traumatic brain injury or meningoencephalitis can develop this disorder.
Kluver-Bucy is associated with herpes simplex virus type 1 (HSV-1) as patients with acute herpes simplex encephalitis can develop this syndrome.
Patients display hyperorality with this disorder. This is characterized by the urge to examine objects orally as well as the insertion of inappropriate objects into the mouth. This can also manifest as hyperphagia, or excessive hunger.
Patients with Kluver-Bucy syndrome often exhibit hypersexuality, defined as excessively frequent or increased sex drive. They are prone to inappropriate sexual compulsions and frequently seeking sexual satisfaction from inappropriate objects.
In this syndrome, patients can have an irresistible impulse to interact and comment on anything they notice. This can lead to inappropriate actions and statements, and even diminished fear response.
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