These tumors are most commonly identified in children, with rare occurrences in adults.
This tumor occurs in the cerebellum and subsequently presents with symptoms of truncal ataxia and wide-based gait.
This tumor can occur in the 4th ventricle, potentially causing obstruction to CSF outflow, with resulting hydrocephalus.
This tumor is characterized by anaplastic small blue cells that are poorly differentiated.
This tumor has the propensity to proliferate rapidly, signified by the presence of many mitotic figures indicating active cell division. This is important to recall when considering the worrisome metastatic potential of this primary CNS tumor.
Rosettes are a stylized floral design used historically in sculpture and architecture. In histology, Homer Wright Rosettes describe tumor cells that are typically characterized as small, round and blue, in rosette patterns around a neuropil. These rosettes are associated with histological findings in medulloblastomas.
This describes the rosette arrangement of cells around a blood vessel rather than a lumen. Perivascular pseudorosettes are mainly found in Ependymomas, however can be found in Medulloblastomas as well.
Rapid growth of this tumor can obstruct CSF outflow and cause hydrocephalus, resulting in nausea, vomiting and papilledema.
Due to the involvement of the cerebellum, many patients have symptoms of truncal ataxia. This presents clinically as a wide-based gait, variable starting and stopping, unequal steps and deviations laterally.
Due to the involvement of the cerebellum, many patients have symptoms of wide-based gait, also called “drunken sailor” gait.
This tumor is exquisitely radiosensitive and can have a high survival rate with radiation therapy.
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