Master Diffuse Proliferative Glomerulonephritis (DPGN) with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Diffuse Proliferative Glomerulonephritis (DPGN)

Pro-Glowing-Mare-Diffused bomb
Nicholazk
10 KEY FACTS
Nephritic and Nephrotic Syndrome
Nerd-cricket Nerd-frog

DPGN generally presents as both nephritic syndrome and nephrotic syndrome. Nephritic syndrome is a renal disorder characterized by hematuria, proteinuria (<3.5g/L/day), hypertension, and red cell casts in the urine. Nephrotic syndrome is characterized by massive proteinuria (≥3.5 g/day) and hypoalbuminemia (serum albumin ≤30 g/L).

ASSOCIATIONS
Systemic Lupus Erythematosus (SLE)
Loopy-butterfly

Autoimmune conditions, particularly systemic lupus erythematosus (SLE), are strongly associated with DPGN. DPGN is the most common renal lesion in patients with SLE, where it is commonly known as "lupus nephritis".

IgA Nephropathy
(IgA) Apple-goblin with Kidney

IgA nephropathy (Berger's disease) is a type of nephropathy that occurs when IgA antibodies build up in the mesangium of the kidney. IgA nephropathy is associated with diffuse proliferative glomerulonephritis.

CHARACTERISTICS
Wire Looping
Caterpillar-Wire

On renal biopsy, glomerular capillaries stain red and appear acellular and thickened due to heavy deposition of subendothelial immune complexes. This leads to the typical appearance of "wire looping."

IF Granular
Fluorescent Grains

Immunofluorescent microscopy (IF) shows granular deposits in the subendothelial and subepithelial sites. These deposits are usually made up of IgG-based immune complexes and C3.

Subendothelial Immune Complexes
Sub-in-donut

Subendothelial deposits are common in patients with diffuse proliferative glomerulonephritis. Subendothelial deposits are located between the endothelium and glomerular basement membrane.

Subepithelial Immune Complexes
Sub-E-pick

Immune complexes are also deposited at subepithelial spaces. Subepithelial spaces are located between podocyte foot processes and the glomerular basement membrane.

C3 Deposition
C3-Laptop

DPGN is associated with the deposition of complement C3 in the subendothelial, subepithelial and intramembranous spaces of the glomerulus.

TREATMENT
Treat Underlying Disorder
Treating Disorders Under the Table

Treatment of diffuse proliferative glomerulonephritis should address underlying conditions (e.g., SLE, IgA nephropathy). Oftentimes, immunosuppressants (e.g., steroids, cyclophosphamide) are effective for inflammation characteristic of diffuse proliferative glomerulonephritis as well as the underlying pathology.

Steroids
Steroid-stairs

High-dose steroids are the mainstay treatment for diffuse proliferative glomerulonephritis. Other immunosuppressants (e.g., cyclophosphamide, mycophenolate mofetil) can be used in refractory cases.

Unlock all 10 facts & definitions with Picmonic Free!

Take the Diffuse Proliferative Glomerulonephritis (DPGN) Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,210,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.