Hodgkin lymphoma has distinctive morphologic features, particularly characterized by the presence of neoplastic giant cells called Reed-Sternberg cells. Reed-Sternberg cells release factors that induce the accumulation of reactive lymphocytes, macrophages, and granulocytes. These cells have a characteristic appearance with two nuclear lobes, large inclusion like nucleoli and abundant cytoplasm.
Reed-Sternberg cells have a characteristic appearance with two nuclear lobes, large inclusion like nucleoli and abundant cytoplasm.
Reed-Sternberg cells are commonly described as having an "owl's eye" appearance, due to the presence of two nuclear lobes with abundant cytoplasm.
Reed-Sternberg cells have a characteristic immunophenotype including CD15 and CD30, while being negative for other B cell markers.
In the majority of Hodgkin lymphomas, the neoplastic Reed-Sternberg cells are derived from germinal centers of B cells.
This cancer is one of the most common cancers of adolescents and young adults, but also has a bimodal age distribution as disease incidence again increases with age. The initial peak is found in young adults (age 15-34), while the second occurs is in older adults (>55 years old).
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