Diffuse large B cell lymphoma is the most common type of non-Hodgkin’s lymphoma (NHL) in the United States.
This lymphoma usually occurs in older adults with a median patient age of 60 but approximately 20% of these neoplasms occur in children as well.
This lymphoma usually occurs in older adults with a median patient age of 60 but approximately 20% of these neoplasms occur in children as well.
Approximately 20% of diffuse large B cell lymphomas are of T-cell origin.
Diffuse large B cell lymphomas are most commonly of B cell origin and are derived from the germinal center. The mature B cell tumors express CD19 and CD20 markers and demonstrate variable expression of germinal center markers including CD10 and BCDL6.
Clinically, patients with this form of lymphoma present with advanced disease with extranodal involvement. Common extranodal sites include the gastrointestinal tract, brain, skin, and bone.
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