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Hypersensitivity Type III reaction occurs due to circulating antigen-antibody immune complexes that deposit in various locations (especially vessel walls) and cause inflammation. It can result in systemic (i.e. Serum sickness) or local immune complex disease (i.e. Arthus reaction).

6 KEY FACTS

Antibody circulating within blood vessels attaches to antigen forming circulating immune complexes that then deposit in various locations.

These immune complexes activate complement via antibody binding to Fc receptors of leukocytes. This results in inflammation.

Inflammation occurs due to neutrophil release of lysosomal enzymes and reactive oxygen intermediates.

This is an example of a local immune complex disease that usually occurs in the skin.

This is an example of systemic immune complex disease that occurs due to a patient receiving non-human animal serum in significant amounts.

This is a chronic type of serum sickness that occurs due to antibody formation against nuclear antigens.

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