Beat The Heat SAVE 25% NOW
Medicine (MD/DO)
Coagulation & Bleeding Disorders
Glanzmann Thrombasthenia

Master Glanzmann Thrombasthenia with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Glanzmann Thrombasthenia

Recommended Picmonics

picmonic thumbnail
Bleeding Time Lab Values
picmonic thumbnail
Bernard-Soulier Syndrome
picmonic thumbnail
Thrombotic Thrombocytopenic Purpura (TTP)
picmonic thumbnail
Hemolytic Uremic Syndrome (HUS)
picmonic thumbnail
Heparin Induced Thrombocytopenia (HIT)

Glanzmann Thrombasthenia

Glass-man with Trombone
Glanzmann’s Thrombasthenia is a genetic or acquired defect in the GPIIb/IIIa platelet receptor that normally binds fibrinogen and facilitates platelet aggregation. This qualitative platelet defect manifests with symptoms such as mucosal bleeding and easy bruising, while lab tests show an increased bleeding time but a normal platelet count. These patients are advised against taking NSAIDs, which further prevent platelet aggregation and may exacerbate bleeding.
Autosomal Recessive or Acquired as an Autoimmune Disorder
Recessive-chocolate and Auto-in-moon

Glanzmann’s thrombasthenia is most often an autosomal recessive disease, meaning that both parents must each pass on one mutated allele for the offspring to be affected. Rarely, patients can acquire the disease if they form autoantibodies to their GPIIb/IIIa receptors.

Deficiency of Glycoprotein IIb/IIIa (Gp IIb/IIIa) Receptor
Broken Glider-protein with (2) Tutu Bee and (3) Tree Apples

The GPIIb/IIIa receptors anchor platelets to each other by binding fibrinogen on neighboring platelets. Since platelets are unable to clump together, platelet plugs cannot form, and primary hemostasis does not begin. In contrast, Bernard-Soulier syndrome involves the deficiency of the GPIb receptor, which affects the binding of von Willebrand factor to platelets.

Defective Platelet-to-Platelet Aggregation
Broken Plates can’t Aggregate

Without GPIIb/IIIa receptors on their surface to bind fibrinogen, adjacent platelets are unable to bind to one another and form a platelet plug as part of primary hemostasis. Drugs such as abciximab used for anticoagulation during angioplasty take advantage of this mechanism by blocking GpIIb/IIIa receptors.

Mucous Membrane Bleeding (Gingival Bleeding)
Mucous Dripping and Bleeding

Patients with platelet disorders may exhibit mucosal bleeding, which may manifest as epistaxis, hemoptysis, menorrhagia, or gingival and GI bleeds.

Easy Bruising
Easy-button Bruising

Patients with platelet disorders may exhibit easy bruising, petechiae, purpura, and ecchymoses.

Increased Bleeding Time
Up-arrow Blood Clock

Because platelets have difficulty aggregating and forming a platelet plug, patients have a prolonged bleeding time. This test is rarely performed today but is still tested on exams.

Normal Platelet Count
Normal Plates

Affected patients have a normal platelet count, in contrast to Bernard-Soulier syndrome, in which patients have sparse, enlarged platelets.

Avoid NSAIDs
Avoid-sign N-sad

NSAIDs non-selectively inhibit cyclooxygenase (COX), an enzyme that produces thromboxane A2, a protein that promotes platelet plug formation. Patients with Glanzmann’s thrombasthenia should not take NSAIDs, as their platelets already are unable to aggregate properly.


Take the Glanzmann Thrombasthenia Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,910,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.