Master Primary Sclerosing Cholangitis Mechanisms with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Primary Sclerosing Cholangitis Mechanisms

Recommended Picmonics

picmonic thumbnail
Primary Sclerosing Cholangitis Labs and Treatment
picmonic thumbnail
picmonic thumbnail
Primary Biliary Cholangitis (Primary Biliary Cirrhosis)
picmonic thumbnail
Primary Biliary Cholangitis (Primary Biliary Cirrhosis) Diagnosis and Treatment
picmonic thumbnail
Clonorchis Sinensis

Primary Sclerosing Cholangitis Mechanisms

#1 Foam-finger Skull-roses Cola-angel with Mechanisms
This disease results in inflammation and fibrosis of intrahepatic and extrahepatic bile ducts. It is visible as “beading” on radiographs of the biliary tree and in symptomatic patients they present with pruritus and fatigue that can lead to jaundice and hepatosplenomegaly.
Unknown Mechanism
Question-mark Mechanism

It is believed that primary sclerosing cholangitis may be caused by autoimmune destruction of bile ducts. However, there are competing theories and the mechanism is not fully understood.

"Onion Skin" Fibrosis

Histologically, fibrosis of bile ducts resembles the layers of an onion. This is known as concentric periductal fibrosis.

"Beading" of Bile Ducts
Beading at Bile-duck with Beads

This is visible on radiographs of the intrahepatic and extrahepatic biliary tree. "Beading” is a manifestation of the strictures and dilations of the bile ducts that occur due to inflammation and fibrosis.


Itchiness, along with fatigue, are often presenting symptoms of primary sclerosing cholangitis. However, similar to other cholestatic causes of pruritus, this mechanism is poorly understood.


Chronic and extensive liver inflammation and fibrosis that is progressive and pervasive in primary sclerosing cholangitis lends itself to the development of hepatosplenomegaly.


As the disease process and liver dysfunction progress, bilirubin metabolism and excretion malfunctions and accumulates, resulting in the characteristic yellow discoloration of the skin called jaundice. Similarly, dark urine may also be present in these patients, manifesting kidney excretion of excess bilirubin.


Take the Primary Sclerosing Cholangitis Mechanisms Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,820,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.