MS is more common in women than men, at a 2:1 ratio.
Individuals with MS most often present in their 20s and 30s.
MS is most common in individuals of Northern European descent.
The mechanism for autoimmune demyelination is not completely understood; however, there is a genetic factor in addition to environmental.
There is an association with the HLA-DRB1 haplotype and MS.
It is believed that T-Cells react against self myelin antigens leading to recruitment of macrophages and leukocytes. This causes demyelination of the CNS.
White matter of the brain and spinal cord are particularly impacted, as white matter is composed chiefly of long-range myelinated axon tracts.
It is believed that T-Cells attack self myelin, recruiting macrophages and leukocytes. Thus, it is hypothesized that T-Cells are likely responsible for autoimmune inflammation reactions in MS.
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