Master Amyloidosis with Picmonic for Medicine

There are several distinct forms of amyloid proteins and the most common forms include AL (amyloid light chain) derived from Ig light chains from plasma cells and AA (A amyloid) derived from a non Ig protein from the liver. The AL form derived from Ig light chains is commonly called primary amyloidosis and is associated with multiple myeloma.

Multiple myeloma (MM) is a malignancy of plasma cells. Normal plasma cells produce immunoglobulins, which are proteins composed of two heavy chains and two light chains. In MM, the abnormal cells produce only light chains instead. These light chains build up in various tissues and cause the disease known as AL amyloidosis

In any inflammatory state, the body releases proteins called acute phase reactants. One of these is named serum amyloid A (AA), a small protein produced by the liver. In chronic inflammatory states like rheumatologic diseases or chronic infection, huge amounts of amyloid A are produced, and are deposited in various tissues. This causes the disease known as secondary AA amyloidosis

Because tuberculosis is often a chronic infection, it induces a chronic inflammatory state. This causes the liver to overproduce amyloid A, leading to secondary AA amyloidosis.

Because rheumatoid arthritis is a chronic inflammatory state, this causes the liver to overproduce amyloid A, leading to secondary AA amyloidosis.

On light microscopy and H and E stains, amyloid appears as eosinophilic, hyaline, extracellular substance that can encroach on and produce pressure atrophy of adjacent tissue. To differentiate amyloid from other hyaline deposits like collagen and fibrin, a Congo red stain is commonly used which produce an apple green birefringence when viewed under polarized light.

On light microscopy and H and E stains, amyloid appears as eosinophilic, hyaline, extracellular substance that can encroach on and produce pressure atrophy of adjacent tissue. To differentiate amyloid from other hyaline deposits like collagen and fibrin, a Congo red stain is commonly used which produce an apple green birefringence when viewed under polarized light.

Nephrotic syndrome is the combination of heavy proteinuria (3.5g/day) with other clinical findings such as generalized edema, hypoalbuminemia, and hyperlipidemia. It has many etiologies, one of which is amyloidosis. When amyloid proteins are deposited in the kidneys, they prevent normal glomerular function and result in proteinuria and therefore nephrotic syndrome.