Patients with moderate persistent asthma have symptoms of cough, difficulty breathing and wheezing every day. Use of a rescue inhaler (short-acting beta-agonist) is required daily to control symptoms.
Symptoms awake the patient from sleep at least once per week, but do not occur every night.
Pulmonary function tests begin to show a decrease in moderate persistent disease. Forced expiratory volume in one second (FEV1) is between 60% and 80% of predicted normal.
The FEV1:FVC (forced vital capacity) ratio is reduced by up to 5%.
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