Master Diamond-Blackfan Anemia with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Diamond-Blackfan Anemia

Diamond Black-fan Anemone
Arwa_Bohra
Diamond-Blackfan Anemia is a type of pure red cell aplasia that presents as macrocytic anemia in infancy. On examination, the patient may display short stature, craniofacial anomalies, and triphalangeal thumbs. Labs will show increased fetal hemoglobin. Patients can be managed with red blood cell transfusion and steroids. Allogenic stem cell transplantation is curative.
9 KEY FACTS
CHARACTERISTICS
Red Blood Cell Aplasia
RBC Plate

Red Blood Cell Aplasia is the absence of erythroid precursors in the bone marrow leading to decreased reticulocytes. It is thought to be due to IgG antibodies against erythroblasts.

Macrocytic Anemia
Macaroni Anemone

Macrocytic anemia is defined as anemia with a red blood cell mean corpuscular volume (MCV) of greater than 100. It is mainly due to DNA maturation defects. In Diamond-Blackfan anemia, this is a consequence of “stress erythropoiesis” and skipped erythroid cell divisions.

CLINICAL FEATURES
Short Stature
Shorts Statue

A child who is less than two standard deviations below the mean in height for children of the same age and sex is said to have short stature, which is characteristic of this disease.

Craniofacial Anomalies
Crane Building Face and Anomaly-Animal

Craniofacial abnormalities like microcephaly, micrognathia, hypertelorism, flat nasal bridge, and cleft palate may be evident in these patients.

Triphalangeal Thumbs
Triphalangeal Thumbs-Up

Normally the thumb has two phalanges (proximal and distal). If it has three phalanges, it is called triphalangeal thumb. Patients with DBA can often demonstrate this clinical feature.

DIAGNOSIS
Increased HbF (Fetal Hemoglobin)
Up-arrow He-man-globe with Fetus

Fetal circulation has hemoglobin made up of two alpha chains and two gamma chains. It has a higher affinity for oxygen than adult hemoglobin. In Diamond Blackfan anemia, HbF is elevated but total hemoglobin levels are low.

MANAGEMENT
RBC Transfusion
Blood Transfusion

Patients receiving chronic red cell transfusion therapy generally require transfusions of 10 to 15 mL/kg every 3 to 5 weeks to maintain a hemoglobin level of more than 8 g/dL.

Steroids
Steroid-stairs

In Diamond-Blackfan anemia, abnormal T cell function leads to IgG antibodies against erythroid progenitor cells. Immunosuppression is therefore important.

Hematopoietic Stem Cell Transplantation
Stems with Blood Cells in Transplant Train-plant

Allogeneic hematopoietic stem cell transplantation is the only curative option for patients with Diamond-Blackfan anemia. Pluripotent stem cells are transplanted from a donor with healthy RBCs.

Unlock all 9 facts & definitions with Picmonic Free!

Take the Diamond-Blackfan Anemia Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,180,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.