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Krukenberg Tumor

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Krukenberg tumors are caused by metastasis to the ovaries from a separate primary location. This is thought to occur through retrograde lymphatic spread, and tumors often present bilaterally. Common primary tumor sources include metasases from both gastric and breast malignancies, although gastrointestinal malignancy at the pylorus is the most frequent source. Microscopically, mucin-secreting signet cells are a defining characteristic of this tumor type.

5 KEY FACTS

Krukenberg Tumors are caused by metastasis to the ovaries from a separate primary location and often present bilaterally.

Metastasis from a separate primary tumor to the ovaries often occurs through retrograde lymphatic spread.

Common primary tumor sources include metasases from gastric cancer and breast cancer.

Malignancy from the gastrointestinal tract, especially adenocarcinoma at the pylorus, is the most common cause.

Tumors can be identified microscopically through the presence of mucin-secreting signet cells in the ovarian tissue. Similar cells are typically found at the primary tumor as well.

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