Granulosa cell tumors are categorized as sex cord-gonadal stromal tumors, and arise from granulosa cells.
Granulosa cell tumors present as a potentially malignant, yellow-white mass. They may also be referred to as granulosa-theca cell tumors.
Unopposed excess estrogen from granulosa cell tumors may cause endometrial carcinoma and hyperplasia in adults.
Call-Exner bodies are small follicles filled with eosinophilic secretions associated with granulosa cell tumors.
Granulosa cell tumors are estrogen-producing and can spur early onset of puberty of abnormal uterine bleeding. Excess estrogen is also a risk factor for endometrial carcinoma.
Unopposed excess estrogen from granulosa cell tumors may result in early onset of puberty in younger patients.
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